Chaotic Oscillations in CMOS Integrated Circuits

Chaos is a purely mathematical term, describing a signal that is aperiodic and sensitive to initial conditions, but deterministic. Yet, engineers usually see it as an undesirable effect to be avoided in electronics. The first part of the dissertation deals with chaotic oscillation in complementary metal-oxide-semiconductor integrated circuits (CMOS ICs) as an effect behavior due to high power microwave or directed electromagnetic energy source. When the circuit is exposed to external electromagnetic sources, it has long been conjectured that spurious oscillation is generated in the circuits. In the first part of this work, we experimentally and numerically demonstrate that these spurious oscillations, or out-of-band oscillations are in fact chaotic oscillations. In the second part of the thesis, we exploit a CMOS chaotic oscillator in building a cryptographic source, a random number generator. We first demonstrate the presence of chaotic oscillation in standard CMOS circuits. At radio frequencies, ordinary digital circuits can show unexpected nonlinear responses. We evaluate a CMOS inverter coupled with electrostatic discharging (ESD) protection circuits, designed with 0.5 μm CMOS technology, for their chaotic oscillations. As the circuit is driven by a direct radio frequency injection, it exhibits a chaotic dynamics, when the input frequency is higher than the typical maximum operating frequency of the CMOS inverter. We observe an aperiodic signal, a broadband spectrum, and various bifurcations in the experimental results. We analytically discuss the nonlinear physical effects in the given circuit : ESD diode rectification, DC bias shift due to a non-quasi static regime operation of the ESD PN-junction diode, and a nonlinear resonant feedback current path. In order to predict these chaotic dynamics, we use a transistor-based model, and compare the model's performance with the experimental results. In order to verify the presence of chaotic oscillations mathematically, we build on an ordinary differential equation model with the circuit-related nonlinearities. We then calculate the largest Lyapunov exponents to verify the chaotic dynamics. The importance of this work lies in investigating chaotic dynamics of standard CMOS ICs that has long been conjectured. In doing so, we experimentally and numerically give evidences for the presence of chaotic oscillations. We then report on a random number generator design, in which randomness derives from a Boolean chaotic oscillator, designed and fabricated as an integrated circuit. The underlying physics of the chaotic dynamics in the Boolean chaotic oscillator is given by the Boolean delay equation. According to numerical analysis of the Boolean delay equation, a single node network generates chaotic oscillations when two delay inputs are incommensurate numbers and the transition time is fast. To test this hypothesis physically, a discrete Boolean chaotic oscillator is implemented. Using a CMOS 0.5 μm process, we design and fabricate a CMOS Boolean chaotic oscillator which consists of a core chaotic oscillator and a source follower buffer. Chaotic dynamics are verified using time and frequency domain analysis, and the largest Lyapunov exponents are calculated. The measured bit sequences do make a suitable randomness source, as determined via National Institute of Standards and Technology (NIST) standard statistical tests version 2.1

Lithography-Free Route to Hierarchical Structuring of High-chi Block Copolymers on a Gradient Patterned Surface

A chemically defined patterned surface was created via a combined process of controlled evaporative self-assembly of concentric polymer stripes and the selective surface modification of polymer brush. The former process involved physical adsorption of poly (methyl methacrylate) (PMMA) segments into silicon oxide surface, thus forming ultrathin PMMA stripes, whereas the latter process was based on the brush treatment of silicon native oxide surface using a hydroxyl-terminated polystyrene (PS-OH). The resulting alternating PMMA- and PS-rich stripes provided energetically favorable regions for self-assembly of high <mml:semantics>chi</mml:semantics> polystyrene-block-polydimethylsiloxane (PS-b-PDMS) in a simple and facile manner, dispensing the need for conventional lithography techniques. Subsequently, deep reactive ion etching and oxygen plasma treatment enabled the transition of the PDMS blocks into oxidized groove-shaped nanostructures

Coins and Logic

We establish fun parallels between coin-weighing puzzles and knights-and-knaves puzzles.Comment: 18 pages, 2 figure

Global gene-expression profiles of intracellular survival of the BruAb2_1031 gene mutated Brucella abortus in professional phagocytes, RAW 264.7 cells

Background Since recognizing the interaction between Brucella and host cells is crucial to the elucidation of the infectious process, Brucella researches have prioritized the investigation of genes related to pathogenicity. To demonstrate the roles of Brucella genes, RAW 264.7 cells were infected with the Brucella abortus wild-type and mutant strains (generated using transposon mutagenesis), after which the different transcriptional responses of the infected cells were determined using microarray. Results Following infection, enhanced strategies for intracellular survival, such as down-regulation of genes associated with cytokine responses and apoptosis, were observed in RAW 264.7 cells infected with C3 mutant strain when compared to the transcriptional responses of wild-type infected cells. Using sequence analysis, we determined the mutation site of a C3 mutant strain as the ATP-binding cassette transporter permease (BruAb2_1031). These results were evidenced by an increased level of intracellular survival of the C3 mutant strain. Conclusions Characteristics of each mutant strain including bacterial growth rate, abilities to induce cytokine production in macrophages after infection, internalization, and levels of intracellular survival and replication, were investigated by performing RAW 264.7 cell infection experiments. Our results indicate that the BruAb2_1031 gene might be closely related with intracellular survival of B. abortus in RAW 264.7 cells.This work was supported by NRF grant of MSIP (No. 2014R1A2A2A01007291), Korea Health Industry Development Institute (HI16C2130), BK21 PLUS and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea. The funders had no role in study design, data collection and interpretation, writing the manuscript and the decision to submit the work for publication

Effect of the submandibular push exercise using visual feedback from pressure sensor: an electromyography study

We developed a new exercise method called the submandibular push exercise that can strengthen the suprahyoid muscle by inducing only the motion of the hyoid bone without neck flexion. In this study, we aimed to investigate and compare the muscle activity of the suprahyoid and infrahyoid muscles in the course of performing three different swallowing exercises. Twenty healthy participants and fifteen patients with dysphagia were recruited. Each participant consecutively performed three exercises: Shaker, CTAR, and submandibular push exercises. To investigate muscle activation, surface electromyography was performed on the suprahyoid, infrahyoid, and SCM muscles, during the exercises. Root mean square (RMS) was measured. In healthy participants, the submandibular push exercise showed a significantly higher RMS value in the suprahyoid and infrahyoid muscles than the Shaker and CTAR exercises using repeated ANOVA with Tukey's post hoc test (p<0.05). In patients with dysphagia, the submandibular push and Shaker exercises showed significantly higher RMS value in the suprahyoid and infrahyoid muscles than the CTAR exercise. However, no significant difference was found between the submandibular push and Shaker exercises. In both healthy and patients with dysphagia, the mean RMS values of the SCM muscles during the submandibular push exercise were significantly lower than those during the Shaker exercise using repeated ANOVA with Tukey's post hoc test (p<0.05). In conclusion, considering the relatively superior selectiveness in suprahyoid and infrahyoid muscle contraction, the submandibular push exercise using visual feedback from pressure sensor could be an efficient supplementary exercise to the conventional swallowing muscle exercises. However, further studies may be necessary to confirm the improvement in swallowing difficulty

Alpha-2-Macroglobulin as a New Promising Biomarker Improving the Diagnostic Sensitivity of Bovine Paratuberculosis

Johne's disease (JD) is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), which induces persistent diarrhea and cachexia. JD causes huge economic losses to the dairy industry due to reduced milk production and premature culling. Infected animals excrete MAP via feces during the prolonged subclinical stage without exhibiting any clinical signs. Therefore, accurate detection of subclinical stage animals is crucial for successful eradication of JD in the herd. In the current study, we analyzed serum samples of MAP-infected and non-infected cattle to identify potential biomarker candidates. First, we identified 12 differentially expressed serum proteins in subclinical and clinical shedder groups compared to the healthy control group. Second, we conducted ELISA for three selected biomarkers (alpha-2-macroglobulin (A2M), alpha-1-beta glycoprotein, and transthyretin) and compared their diagnostic performance with that of two commercial ELISA diagnostic kits. Serum A2M levels were significantly higher in the MAP-exposed, subclinical shedder, subclinical non-shedder, and clinical shedder groups than in the healthy control group, suggesting its possible use as a diagnostic biomarker for MAP infection. Furthermore, A2M demonstrated a sensitivity of 90.4%, and a specificity of 100% while the two commercial ELISA kits demonstrated a sensitivity of 67.83 and 73.04% and a specificity of 100%, respectively. In conclusion, our results suggest that measuring A2M by ELISA can be used as a diagnostic tool to detect MAP infection, considerably improving the detection rate of subclinical shedders and MAP-exposed animals that are undetectable using current diagnostic tools

A novel repeat sequence-based PCR (rep-PCR) using specific repeat sequences of Mycobacterium intracellulare as a DNA fingerprinting

Repetitive sequence-based PCR (rep-PCR) is a potential epidemiological technique that can provide high-throughput genotype fingerprints of heterogeneous Mycobacterium strains rapidly. Previously published rep-PCR primers, which are based on nucleotide sequences of Gram-negative bacteria may have low specificity for mycobacteria. Moreover, it was difficult to ensure the continuity of the study after the commercial rep-PCR kit was discontinued. Here, we designed a novel rep-PCR for Mycobacterium intracellulare, a major cause of nontuberculous mycobacterial pulmonary disease with frequent recurrence. We screened the 7,645 repeat sequences for 200 fragments from the genome of M. intracellulare ATCC 13950 in silico, finally generating five primers with more than 90% identity for a total of 226 loci in the genome. The five primers could make different band patterns depending on the genome of three different M. intracellulare strains using an in silico test. The novel rep-PCR with the five primers was conducted using 34 bacterial samples of 7 species containing 25 M. intracellulare clinical isolates, compared with previous published rep-PCRs. This shows distinguished patterns depending on species and blotting assay for 6 species implied the sequence specificity of the five primers. The Designed rep-PCR had a 95–98% of similarity value in the reproducibility test and showed 7 groups of fingerprints in M. intracellulare strains. Designed rep-PCR had a correlation value of 0.814 with VNTR, reference epidemiological method. This study provides a promising genotype fingerprinting method for tracing the recurrence of heterogeneous M. intracellulare

Interactive Q-Learning Approach for Pick-and-Place Optimization of the Die Attach Process in the Semiconductor Industry

In semiconductor back-end production, the die attach process is one of the most critical steps affecting overall productivity. Optimization of this process can be modeled as a pick-and-place problem known to be NP-hard. Typical approaches are rule-based and metaheuristic methods. The two have high or low generalization ability, low or high performance, and short or long search time, respectively. The motivation of this paper is to develop a novel method involving only the strengths of these methods, i.e., high generalization ability and performance and short search time. We develop an interactive Q-learning in which two agents, a pick agent and a place agent, are trained and find a pick-and-place (PAP) path interactively. From experiments, we verified that the proposed approach finds a shorter path than the genetic algorithm given in previous research